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In vitro fertilization (IVF) is the most common type of assisted reproductive technology (ART), used to create an embryo by bypassing certain causes of infertility, such as mild sperm abnormalities in men, and fallopian tube or ovulation irregularity in women.

During IVF, a woman’s eggs are surgically retrieved and then fertilized in a laboratory by mixing with a partner (or donor’s) sperm. The fertilized egg, or embryo, is left to grow for two to five days and is then surgically transferred back into the woman’s womb.


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What is Preimplantion Genetic Diagnosis?

Preimplantation genetic diagnosis (PGD) is a reproductive technology used along with an IVF cycle to increase the potential for a successful pregnancy and delivery. PGD is a genetic test on cells removed from embryos, to help select the best embryo(s) to achieve pregnancy or to avoid a genetic disease for which a couple is at risk.

Who should consider PGD?

PGD may be considered in all IVF cycles; however, those who might benefit most from this test are couples at increased risk for chromosome abnormalities or specific genetic disorders. This includes women who have had several miscarriages, or who have had a prior pregnancy with a chromosome abnormality. Women over 38 years of age and men with some types of sperm abnormalities may produce embryos with higher rates of chromosome abnormalities. This test is also known as PGT-A (aneuploidy). In addition, if a person carries a structural rearrangement of the chromosomes, PGD can identify which embryos have a normal amount of chromosomal material. This technology is also known as PGT-SR (structural rearrangement). When there is a 25% or 50% chance to have a child affected with a specific genetic disease, PGD can be designed to identify which embryos are affected, unaffected, or a carrier (if applicable) for that disease. Then, only embryos without the disease are transferred to the uterus to attempt pregnancy. This is also known as PGT-M (monogenic disorders).

What are the PGD steps during an IVF cycle?

After embryos are created in the laboratory, they are grown for five to six days. On day five or on day six, the biopsy for PGD is done on all appropriately developing embryos. Biopsy involves removing a few cells from the trophectoderm, or the layer of cells that is ‘hatching out’ of the embryo at this stage of development. The embryos are stored while genetic material inside the removed cells is tested for abnormalities. One of Genetic & IVF’s genetic counselors discusses PGD test results with the woman/couple, and a frozen embryo transfer (FET) cycle is planned for use of the embryo(s). Decisions regarding selection of embryos to transfer into the uterus are made with the advice of both the medical and genetics team.

Is embryo biopsy and PGD safe?

Yes. Data from many years of PGD in animals and several hundred thousand live births in humans indicate that PGD does not lead to an increase in birth defects over that of the general population. Follow-up evaluation of children born after PGD does not show any evidence for a detrimental effect of the process on growth or neurological development over the first several years of life. In embryos where chromosomal PGD testing is performed, one can expect fewer pregnancies ending in miscarriages due to chromosomal disorders since most abnormalities are identified prior to transfer of the embryos to the uterus. Removal of a few of the trophectoderm cells of the early embryo does not alter the ability of that embryo to develop into a complete, normal pregnancy.

How are embryos chosen for transfer?

Embryos that have both a normal test result and appearance (morphology) can be transferred in a frozen embryo transfer (FET) cycle. While embryo morphology can be helpful in selecting the best embryos for transfer, it is known that many embryos with significant chromosome abnormalities have normal morphology. Therefore, PGD results help to better identify the best embryos to transfer to the uterus to achieve a successful pregnancy. The combination of normal genetic testing with normal physical appearance indicates the highest chance of becoming a healthy pregnancy. All decisions regarding which embryo(s) to transfer to the uterus and how to use the remaining embryos are made together between the couple and their medical team.


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Every single patient visiting us always ask this question “Are IVF Babies as Normal as Others?”, so today we have decided to crack this commonly asked question.

Since IVF is in developing stage in our society, many people   harbour a lot of pre-conceived thoughts. One common which is prevalent even among the educated class is that  How IVF baby can be normal because they are not achieved with sexual intercourse but they have been made in the laboratory, Believe me its very hard to make them understand on this question. Today I want to make them understand scientifically.

1 How female get pregnant normally?

Normally male partner introduce sperm into vagina through sexual intercourse.

If sexual intercourse is done near time period of ovulation ,sperm enter into ovum and they make baby together.but for that we need absolutely normal sperm,ovum and their travelling tract.

2 what we do in IVF?

we select your best sperm,ovum bypasses their travelling tract and make healthy embryo  outside maternal womb and introduce embryo into Uterus at the time of Embryo transfer after that whole process remain same.so we are just bypassing the hurdles in the way of sperm and ovum to make healthy embryo.we are not making babies with any super chemical or drugs in our laboratory. Now it has been 40 years of first IVF baby (Lewis brown) birth and she is also mother of two sons which she conceived normally, so its well understood that IVF BABIES ARE AS NORMAL AS OTHERS.

Hope you understand this question and answer.

Feel free to ask any question regarding infertility.


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The procedure for freezing a woman’s eggs is commonly known as egg freezing, social freezing, and human oocyte cryopreservation. Egg freezing was developed as a method of fertility preservation. This is beneficial for a preserving a woman’s eggs who is being treated for a serious illness, such as cancer, and needs to delay starting a family. Cryopreservation is not only effective in oncofertility treatments; the technique is also available for women who want to delay childbearing or are concerned about her fertility.

Benefits of  Egg Freezing

There are many reasons why, as a woman, you may choose to delay having children. You may have career or educational goals to meet. You may wish to travel, achieve financial independence, or simply enjoy your relationship before starting a family.  Freezing removes the pressure of the ‘biological clock’ by providing an option to freeze eggs while you have good ovarian reserve and egg quality. You can then use those eggs at a later date when your personal circumstances are right for motherhood, even if your age would make natural conception difficult.

When Should I Freeze My Eggs?

The simple answer to this question is: “As soon as possible!” As women age, the quality and quantity of egg production declines; gradually while in her 20’s and then dramatically once she reaches 35 years old. At each menstruation, several hundreds of her eggs die. Each woman is born with a fixed number of eggs and as she ages, she will never produce more. Because of this, women in their early 30’s who are not yet ready to be parents might strongly consider social egg freezing as a method to preserve their current level of fertility. While it is true that some women are able to have natural births even in their forties and beyond, social freezing your eggs at a younger age allows for more potential treatment options as you age. There are certain hormone tests that your Aspire physician can perform to get an idea of how many eggs your ovaries might produce when stimulated with IVF medications. However, these tests are not able to estimate the number of eggs a woman may have at the time of testing. Commonly known as ovarian reserve tests, these tests are a useful tool, but not a crystal ball. Since there is no way to tell how many eggs a woman has, this is another reason why women should consider egg freezing at as young an age as possible. Women who are attempting to get pregnant will have better outcomes before age 35 than after. The same thing is true for egg freezing: women considering social freezing can enhance their chances of success by completing a social freeze before age 35.

How Does Egg Freezing Work?

As part of the egg freezing process, you will undergo the same cycle of hormone medications that are used for IVF treatment process. You will have all the same appointments, tests, and procedures that will cause your body to produce as many healthy eggs as you can safely produce at the time of egg retrieval.  This process is called ovarian stimulation.  During the stimulation process, the clinical team at Aspire will closely monitor your hormone levels to ensure that your body responds effectively and safely to IVF medications. After egg retrieval, eggs are flash frozen through a process known as vitrification.  Egg cells, knowns as oocytes, are the largest cells produced in the body, and contain a high volume of water.  When frozen through normal processes, the water inside of our cells (including oocytes) forms into jagged ice crystals that destroy the surrounding tissue and compromise cell integrity.  In order for oocytes to survive the freezing, the thawing process, and later be viable for IVF, additional steps must be taken to prevent ice crystal formation. This is primarily accomplished through the use of cryoprotectants which take the place of water in the cells and prevent the formation of ice crystals. Cryopreserved eggs are then vitrified, which physically transforms eggs into a solid, stable state.  The resulting glass-like cell is devoid of ice crystals and can be stored indefinitely in our cryopreservation tanks.

Is Egg Freezing Safe?

Egg freezing was first successfully used in IVF in 1999. Since that time, numerous clinical and academic studies have been performed to assess the impact of vitrification on outcomes in IVF patients. As vitrification techniques have improved, these studies have found that egg freezing is safe and in no way impairs the outcome of future IVF attempts. In fact, when used with a standard IVF cycle, vitrification has been shown to improve outcomes, likely by allowing the patient’s body time to normalize her hormone levels after IVF stimulation. Aspire’s leading team of embryologist to use the latest vitrification techniques to ensure the best possible outcomes for all social freezing patients.


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  1. Watch what you feed on: Your diet defines and determines your health. It is very important to keep a regular check on your food intake especially when you are planning a baby. If the food is right, the need for medicines diminishes, making things a little less complex. The good food rule applies to both men and women’s fertility. Nuts and dry fruits, whole grains, eggs, avocados, green leafy vegetables, berries, ginger, sesame seeds, fish/fish oil, beans and lentils, sunflower seeds, and fresh fibrous fruits top the list of best fertility foods. Avoid artificial sweeteners, packaged beverages, ready to eat food, frozen food, and sugar. For women with PCOS, it is advisable to cut down on gluten and lay more emphasis on consuming diverse grains like quinoa, millet, amaranth, buckwheat, sorghum, etc. These foods are known to help in reducing inflammation, keeping blood sugar levels in control and making you feel fuller for longer.
  2. Stay hydrated: Hydration is not only the key to good skin and hair, but also has a major role to play in the health of one’s reproductive system. People generally tend to ignore the importance of staying hydrated at all times. Being dehydrated generally leads to headaches, irritability and fatigue. Dehydration in men can lead to reduced sperm count and decreased volume of semen while dehydration in women can lead to poor quality of egg which ultimately affects her probability of conceiving. On an average, one’s water intake should be anywhere between 2-3 litres per day.
  3. Govern stress: Stress can adversely affect your reproductive health. Fertility is directly linked to hormones and their balance; and stress creates an imbalance of hormones which clearly leads to poor fertility or even infertility. Primarily, stress attacks hypothalamus gland in the brain, disrupts emotions and appetite and those hormones which tell your ovaries to release eggs. These hormonal disturbances affect ovulation and monthly cycles, negatively. On the other hand, reduced stress can increase the blood flow to the uterus and thus help in conceiving easily.
  4. Moderate exercise routine: 40 – 45 minutes of yoga, Pilates, mild cardio, strength and weight training every day, 4 days per week, is a good exercise routine for overall health, including reproductive health. Obesity can lead to infertility while losing weight can help regulate period cycle and ultimately boost fertility. A BMI range of 18.5 to 24.9 is ideal for conceiving. Being underweight and overweight poses threat to fertility, equally.
  5. Monitor alcohol consumption: High levels of alcohol consumption can apathetically affect testosterone level, sperm count and sex drive in men which leads to poor fertility or even impotence. Similarly, alcohol might lead to weight gain, irregular periods and difficult ovulation in women, thus affecting fertility. So women try to conceive are advised to stay away from alcohol for best bet.
  6. Abandon cigarette: Smoking ages your skin, lungs and eggs. Excessive smoking also damages uterus. Men who smoke disrupt their hormone production, thus becoming less fertile. Chances of conceiving can go down by almost 40% if you smoke, hence making it difficult to have a baby. This holds true for passive smokers too.
  7. Record your remedy: Certain medicines needs to be altered, stopped or started when you plan a baby. Maintaining a record of all the medication that a couple is currently taking is good idea so a certified medical practitioner’s advice can be taken with respect to it. Multivitamins, folic acid, and metformin are the most commonly prescribed remedies that help in addressing fertility issues. A gynaecologist or an IVF specialist may prescribe other medicines customised to one’s age and health.
  8. Regular bedroom activity: In the end, what matters the most is having fun in the bed room. The easiest way to increase chances of conception is by having regular sex, making it more fun and less stressful, and enjoying the procedure of making a baby.

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Today we are going to talk about the topic which is touching so many patients now a days. life style and foof habbits has been changed a lot so demon of OBESITY growing larger and larger day by day. Today we will talk about how obesity affect fertility and what we can do to overcome it.

Obesity causes hormonal imbalance

When your body mass index goes past the overweight category (BMI of 25–29.9) into the obese category (BMI of 30 and above), hormonal changes may occur in your body. When your levels of natural hormones change, your chances of conception decrease.

Obesity causes  insulin resistance

The hormonal imbalance that comes with obesity often leads to insulin resistance. That is a major risk factor on the road to diabetes — but it also affects your fertility and can create abnormal menstrual cycles. Insulin resistance can lead to anovulation, in which your body does not produce eggs properly.

Obesity increases miscarriage rate

The association between obesity and miscarriage has been assessed in a number of studies in both natural and assisted conceptions in which the miscarriage risk was as high as up to approximately 40% in obese women with respect to less than 15% in females with a normal BMI.

Influence of obesity on fertility treatments

Overweight and obese women have lower outcomes following fertility treatments than normal population. They poorly respond to induction of ovulation, require higher doses of gonadotropins and longer treatment courses for follicular development and ovulatory cycles. In addition, the oocyte yield is lower in obese women resulting in a higher rate of cycle cancellation . Ovarian stimulation for assisted reproduction produces fewer follicles leading to the harvest of fewer oocytes. Thus, the fertilization rates are scarce and the embryo quality is impaired in younger obese undergoing fertility treatments who definitely show low pregnancy rate with increased risk of early pregnancy loss.

Obesity decreases your partner’s fertility

Although much of the focus on obesity and infertility is on women, it absolutely affects men, too. For men, obesity leads to a drop in testosterone, which can lead to infertility. On top of that, erectile dysfunction occurs at a higher rate among obese men.

Benefits from weight loss

Weight loss has been shown to improve reproductive outcomes by ameliorating fertility, as well as by regularizing menstrual cycles and increasing the chance of spontaneous ovulation and conception in anovulatory overweight and obese women.

Available data suggest that the weight loss equal to 5%–10% of the body weight may definitely improve the fertility rate.


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